In a medium mixing bowl, combine ground chicken, panko breadcrumbs, egg, garlic powder, onion powder, smoked paprika, salt, and pepper.
Divide the mixture into four equal portions and shape into patties approximately 3/4-inch thick.
Preheat the air fryer to 375°F (190°C).
Lightly coat the air fryer basket with olive oil spray.
Place the patties in the air fryer basket in a single layer, ensuring no overlapping.
Cook for 10 to 12 minutes, flipping the patties at the 6-minute mark.
Verify the internal temperature has reached 165°F (74°C) using an instant-read thermometer.
Remove patties from the air fryer and allow to rest for 2 minutes before serving.