Preheat the air fryer to 400°F (200°C).
Pat the chicken thighs dry with paper towels to ensure optimal browning.
In a large bowl, toss the chicken thighs with olive oil until evenly coated.
Combine garlic powder, onion powder, smoked paprika, oregano, salt, and pepper in a small bowl.
Sprinkle the seasoning mixture over the chicken, ensuring all surfaces are covered.
Place the chicken thighs in the air fryer basket in a single layer, ensuring they do not overlap.
Cook for 12 to 15 minutes, flipping the thighs halfway through the cooking time.
Verify the internal temperature has reached 165°F (74°C) using an instant-read thermometer.
Remove from the air fryer and let rest for 5 minutes before serving.