Preheat the oven to 375°F (190°C) and line a rimmed baking sheet or pizza stone with high-quality parchment paper to prevent sticking.
Place the cottage cheese, eggs, Italian seasoning, garlic powder, onion powder, and salt into a high-speed blender.
Pulse until the mixture is completely smooth and liquid with no visible curds.
Transfer the mixture to a bowl and whisk in the flour until just combined and a thin, pourable batter forms.
Pour the batter onto the center of the prepared parchment paper and use a spatula to spread it into a circle approximately 10 inches in diameter and 1/4 inch thick.
Bake the crust in the preheated oven for 25 to 30 minutes, or until the edges are golden brown and the center is set and firm to the touch.
Remove the crust from the oven and let it rest for 2 minutes. Add your desired pizza toppings (sauce, cheese, vegetables).
Return the topped pizza to the oven for an additional 5 to 7 minutes, or until the cheese is melted and bubbly.