Boil pasta in salted water according to package instructions until al dente, then drain.

Brown the ground beef in a large skillet over medium-high heat until no longer pink and drain fat.

Add the undrained Ro*Tel, garlic powder, and onion powder to the skillet and stir.

Incorporate the cubed cream cheese and heavy cream, stirring until the sauce is smooth and the cheese is melted.

Fold in the cooked pasta and shredded cheddar cheese, stirring until the cheese is fully incorporated.

Adjust seasoning with salt and pepper before serving.