Preheat oven to 425°F (220°C) and line a large baking sheet with parchment paper.
Place eggplant slices on paper towels, sprinkle lightly with salt, and let sit for 10 minutes to draw out moisture, then pat dry.
Prepare three shallow bowls: one with flour, one with beaten eggs, and one with a mixture of Panko, Parmesan, garlic powder, oregano, salt, and pepper.
Dredge each eggplant slice in flour, shaking off excess, then dip into the egg wash, and finally coat thoroughly with the Panko mixture.
Arrange the coated slices in a single layer on the prepared baking sheet and lightly spray the tops with cooking spray.
Bake for 20 to 25 minutes, flipping halfway through, until the coating is golden brown and crispy.