Preheat the air fryer to 400°F (200°C).
In a large mixing bowl, combine the ground turkey, breadcrumbs, Parmesan, egg, olive oil, garlic powder, onion powder, oregano, salt, and pepper.
Mix the ingredients by hand until just combined, taking care not to over-compress the meat which can cause toughness.
Form the mixture into balls approximately 1 inch in diameter, yielding roughly 16 to 20 meatballs.
Lightly coat the air fryer basket with cooking spray or a thin layer of oil.
Place the meatballs in the basket in a single layer, ensuring they do not touch to allow for optimal airflow.
Air fry for 10 to 12 minutes, shaking the basket gently at the 6-minute mark to ensure even browning.
Confirm the internal temperature has reached 165°F (74°C) using an instant-read thermometer before serving.