Place a large skillet over medium-high heat and add the lean ground beef.
Cook the beef until fully browned, breaking it into small crumbles with a spatula.
Season the beef with garlic powder, onion powder, salt, and pepper, then remove from heat and allow to cool slightly.
In a small mixing bowl, combine Greek yogurt, light mayonnaise, mustard, ketchup, pickle relish, and smoked paprika to create the dressing.
Arrange four meal prep containers and distribute the shredded Romaine lettuce evenly across them.
Top the lettuce with the cooked ground beef, cherry tomatoes, red onion, pickles, and shredded cheese.
Portion the dressing into four small individual lidded containers to be added just before consumption.
Garnish each bowl with sesame seeds before sealing the containers.