Bring a large pot of salted water to a boil. Cook the high-protein pasta according to package directions until al dente. Drain and set aside.
Season the diced chicken breast with salt, pepper, and smoked paprika.
Heat a large non-stick skillet over medium-high heat. Cook the chicken for 6-8 minutes or until the internal temperature reaches 165°F (74°C).
Reduce the skillet heat to low. Pour 0.25 cup of buffalo sauce over the chicken and toss to coat thoroughly. Remove chicken from the pan and set aside.
In the same skillet over low heat, whisk together the Greek yogurt, milk, garlic powder, onion powder, and the remaining 0.25 cup of buffalo sauce.
Gradually add the shredded cheddar cheese to the yogurt mixture, whisking continuously until the cheese is completely melted and the sauce is smooth. Do not boil, as yogurt may curdle.
Add the cooked pasta and buffalo chicken to the skillet. Gently fold all components together until the pasta is evenly coated in the buffalo cheese sauce.
Garnish with minced chives and serve immediately.