Preheat oven to 375 degrees Fahrenheit (190 degrees Celsius).
Pat chicken breasts dry with paper towels to ensure coating adhesion.
Combine mayonnaise, Parmesan cheese, garlic powder, onion powder, salt, and pepper in a mixing bowl until uniform.
Place chicken breasts in a single layer inside a 9x13 inch baking dish.
Spread the creamy mixture evenly across the top surface of each chicken breast.
Sprinkle seasoned breadcrumbs over the coating.
Bake for 20-25 minutes until the internal temperature reaches 165 degrees Fahrenheit (74 degrees Celsius).
Allow the protein to rest for 5 minutes before slicing to allow juices to redistribute.