Moisten the rim of a rocks glass with a lime wedge and dip into the chili-lime salt until evenly coated.
Place the jalapeño slices into a cocktail shaker and muddle gently to release the oils and capsaicin.
Add the Blanco tequila, mango puree, lime juice, and agave nectar to the shaker.
Fill the shaker with ice cubes and secure the lid.
Shake vigorously for 15 seconds to emulsify the puree and achieve thermal equilibrium.
Double strain the mixture through a fine-mesh sieve into the prepared rocks glass filled with fresh ice to remove jalapeño solids.
Garnish with a lime wheel or an additional jalapeño slice.